aav2 10 Search Results


aav-hsyn-grabado1.0 (aav2/9, 1.52 × 1013 genomic copies ml−1)  (Vigene Biosciences)
90
Vigene Biosciences aav-hsyn-grabado1.0 (aav2/9, 1.52 × 1013 genomic copies ml−1)
Aav Hsyn Grabado1.0 (Aav2/9, 1.52 × 1013 Genomic Copies Ml−1), supplied by Vigene Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aav-hsyn-grabado1.0 (aav2/9, 1.52 × 1013 genomic copies ml−1)/product/Vigene Biosciences
Average 90 stars, based on 1 article reviews
aav-hsyn-grabado1.0 (aav2/9, 1.52 × 1013 genomic copies ml−1) - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
aav 2.31 × 10 12 vg/ml  (SunBio Inc)
90
SunBio Inc aav 2.31 × 10 12 vg/ml
a Representative western blot films for IL-1β, TNF-α, and IL-6 protein expression in the hippocampus of the offspring. The corresponding quantification of b IL-1β, c TNF-α, and d IL-6 in the offspring mice. n = 6 per group; IL-1β: F 2, 15 = 18.93, P < 0.001; TNF-α: F 2, 15 = 15.24, P < 0.01; IL-6: F 2, 15 = 2.95, P < 0.05, one-way ANOVA. e Representative micrographs of Iba1+ cells (green) in the DG. Scale bars: 100 μm. White arrows indicate the cell represented in the inset. Scale bars: 10 μm. f Number of Iba-1+ cells (×20) in the DG of the offspring. n = 6 mice per group; F 2, 15 = 9.34, P < 0.05, one-way ANOVA. g Quantitative analysis for mean ramification index of microglia. n = 6 mice per group; F 2, 15 = 6.546, P < 0.05, one-way ANOVA. h Representative western blot films for <t>Arg1</t> and Ym1 protein expression in the hippocampus of the offspring. The corresponding quantification of i Arg1 and j Ym1 expression levels in the offspring. n = 6 mice per group; Arg1: F 2, 15 = 5.475, P < 0.05; Ym1: F 2, 15 = 1.058, P > 0.05, one-way ANOVA. k Representative fluorescent images for Arg1 immunoreactivity in the DG of offspring mice. Scale bars: 20 μm. l Quantification of Arg1 immunoreactivity (in arbitrary units) in the DG. n = 6 mice per group; F 2, 15 = 4.197, P < 0.05, one-way ANOVA. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s., not significant. Values are the mean ± SEM.
Aav 2.31 × 10 12 Vg/Ml, supplied by SunBio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/aav 2.31 × 10 12 vg/ml/product/SunBio Inc
Average 90 stars, based on 1 article reviews
aav 2.31 × 10 12 vg/ml - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


a Representative western blot films for IL-1β, TNF-α, and IL-6 protein expression in the hippocampus of the offspring. The corresponding quantification of b IL-1β, c TNF-α, and d IL-6 in the offspring mice. n = 6 per group; IL-1β: F 2, 15 = 18.93, P < 0.001; TNF-α: F 2, 15 = 15.24, P < 0.01; IL-6: F 2, 15 = 2.95, P < 0.05, one-way ANOVA. e Representative micrographs of Iba1+ cells (green) in the DG. Scale bars: 100 μm. White arrows indicate the cell represented in the inset. Scale bars: 10 μm. f Number of Iba-1+ cells (×20) in the DG of the offspring. n = 6 mice per group; F 2, 15 = 9.34, P < 0.05, one-way ANOVA. g Quantitative analysis for mean ramification index of microglia. n = 6 mice per group; F 2, 15 = 6.546, P < 0.05, one-way ANOVA. h Representative western blot films for Arg1 and Ym1 protein expression in the hippocampus of the offspring. The corresponding quantification of i Arg1 and j Ym1 expression levels in the offspring. n = 6 mice per group; Arg1: F 2, 15 = 5.475, P < 0.05; Ym1: F 2, 15 = 1.058, P > 0.05, one-way ANOVA. k Representative fluorescent images for Arg1 immunoreactivity in the DG of offspring mice. Scale bars: 20 μm. l Quantification of Arg1 immunoreactivity (in arbitrary units) in the DG. n = 6 mice per group; F 2, 15 = 4.197, P < 0.05, one-way ANOVA. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s., not significant. Values are the mean ± SEM.

Journal: Neuropsychopharmacology

Article Title: Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus

doi: 10.1038/s41386-020-0743-7

Figure Lengend Snippet: a Representative western blot films for IL-1β, TNF-α, and IL-6 protein expression in the hippocampus of the offspring. The corresponding quantification of b IL-1β, c TNF-α, and d IL-6 in the offspring mice. n = 6 per group; IL-1β: F 2, 15 = 18.93, P < 0.001; TNF-α: F 2, 15 = 15.24, P < 0.01; IL-6: F 2, 15 = 2.95, P < 0.05, one-way ANOVA. e Representative micrographs of Iba1+ cells (green) in the DG. Scale bars: 100 μm. White arrows indicate the cell represented in the inset. Scale bars: 10 μm. f Number of Iba-1+ cells (×20) in the DG of the offspring. n = 6 mice per group; F 2, 15 = 9.34, P < 0.05, one-way ANOVA. g Quantitative analysis for mean ramification index of microglia. n = 6 mice per group; F 2, 15 = 6.546, P < 0.05, one-way ANOVA. h Representative western blot films for Arg1 and Ym1 protein expression in the hippocampus of the offspring. The corresponding quantification of i Arg1 and j Ym1 expression levels in the offspring. n = 6 mice per group; Arg1: F 2, 15 = 5.475, P < 0.05; Ym1: F 2, 15 = 1.058, P > 0.05, one-way ANOVA. k Representative fluorescent images for Arg1 immunoreactivity in the DG of offspring mice. Scale bars: 20 μm. l Quantification of Arg1 immunoreactivity (in arbitrary units) in the DG. n = 6 mice per group; F 2, 15 = 4.197, P < 0.05, one-way ANOVA. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s., not significant. Values are the mean ± SEM.

Article Snippet: The Arg1 overexpression AAV (pAAV-CMV-DIO-Arg1-eGFP-2A, 9.38 × 10 12 VG/ml), and control AAV for Arg1 overexpression AAV (2.31 × 10 12 VG/ml), with a serotype of AAV9, were purchased from Sunbio Medical Biotechnology (Shanghai, China).

Techniques: Western Blot, Expressing

a Mice expressing the two transgenes were crossed and injected with tamoxifen. b Arg1 protein level was obviously reduced in the hippocampus of CX3CR1-Arg1 −/− offspring compared with the Arg1 f/f littermates. n = 5 per group; F 1, 8 = 18.75, P < 0.001, one-way ANOVA. c Diagram of poly (I:C) insult, minocycline treatment and behavior test for CX3CR1-Arg1 −/− mice and Arg1 f/f littermates. d Total distance of adult offspring mice in open field test. n = 10 per group; Group: F 2, 27 = 4.852, P < 0.01, two-way ANOVA. e Similar response to 70 dB background noise in the three group. n = 10 mice per group; Group: F 2, 27 = 0.944, p > 0.05, two-way ANOVA. f PPI was impaired in Poly+vehicle offspring of CX3CR1-Arg1 −/− mice compared to Ctrl+vehicle offspring and failed to ameliorate in Poly+Mino offspring. n = 10 mice per group; Group: F 2, 27 = 10.274, P < 0.01, prepulse intensity: F 2, 54 = 26.308, P < 0.001; Group × prepulse intensity: F 4, 54 = 1.773, P > 0.05, three-way ANOVA with repeated measures. g Increased latency for Poly+vehicle offspring of CX3CR1-Arg1 −/− mice to reach the hidden platform compared with Ctrl+vehicle offspring and failed to restore in Poly+Mino mice. n = 10 mice per group; Group: F 2, 27 = 7.670, p < 0.01; day: F 3, 81 = 19.035, p < 0.001; Group × day: F 6, 81 = 1.553, p > 0.05; three-way ANOVA with repeated measures. h In the probe trial, data are presented as percent time and percent distance in the target quadrant. n = 10 mice per group; Group: F 2, 27 = 6.298, p < 0.01, two-way ANOVA. For all figures, there is no “Genotype” or “Genotype × Group” interactions were detected (all p’s > 0.05). For Fig. g * p < 0.05, ** p < 0.01, *** p < 0.001 for Poly+vehicle offspring vs. Ctrl+vehicle offspring, # p < 0.05 for Poly+Mino offspring vs. Poly+vehicle offspring. Values are the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s., not significant.

Journal: Neuropsychopharmacology

Article Title: Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus

doi: 10.1038/s41386-020-0743-7

Figure Lengend Snippet: a Mice expressing the two transgenes were crossed and injected with tamoxifen. b Arg1 protein level was obviously reduced in the hippocampus of CX3CR1-Arg1 −/− offspring compared with the Arg1 f/f littermates. n = 5 per group; F 1, 8 = 18.75, P < 0.001, one-way ANOVA. c Diagram of poly (I:C) insult, minocycline treatment and behavior test for CX3CR1-Arg1 −/− mice and Arg1 f/f littermates. d Total distance of adult offspring mice in open field test. n = 10 per group; Group: F 2, 27 = 4.852, P < 0.01, two-way ANOVA. e Similar response to 70 dB background noise in the three group. n = 10 mice per group; Group: F 2, 27 = 0.944, p > 0.05, two-way ANOVA. f PPI was impaired in Poly+vehicle offspring of CX3CR1-Arg1 −/− mice compared to Ctrl+vehicle offspring and failed to ameliorate in Poly+Mino offspring. n = 10 mice per group; Group: F 2, 27 = 10.274, P < 0.01, prepulse intensity: F 2, 54 = 26.308, P < 0.001; Group × prepulse intensity: F 4, 54 = 1.773, P > 0.05, three-way ANOVA with repeated measures. g Increased latency for Poly+vehicle offspring of CX3CR1-Arg1 −/− mice to reach the hidden platform compared with Ctrl+vehicle offspring and failed to restore in Poly+Mino mice. n = 10 mice per group; Group: F 2, 27 = 7.670, p < 0.01; day: F 3, 81 = 19.035, p < 0.001; Group × day: F 6, 81 = 1.553, p > 0.05; three-way ANOVA with repeated measures. h In the probe trial, data are presented as percent time and percent distance in the target quadrant. n = 10 mice per group; Group: F 2, 27 = 6.298, p < 0.01, two-way ANOVA. For all figures, there is no “Genotype” or “Genotype × Group” interactions were detected (all p’s > 0.05). For Fig. g * p < 0.05, ** p < 0.01, *** p < 0.001 for Poly+vehicle offspring vs. Ctrl+vehicle offspring, # p < 0.05 for Poly+Mino offspring vs. Poly+vehicle offspring. Values are the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s., not significant.

Article Snippet: The Arg1 overexpression AAV (pAAV-CMV-DIO-Arg1-eGFP-2A, 9.38 × 10 12 VG/ml), and control AAV for Arg1 overexpression AAV (2.31 × 10 12 VG/ml), with a serotype of AAV9, were purchased from Sunbio Medical Biotechnology (Shanghai, China).

Techniques: Expressing, Injection

a Schematic diagram showing the experimental strategy for Arg1 overexpression. AAV-DIO-Arg1-GFP was stereotactic injected into hippocampus DG of CX3CR1-creER mice. b Timeline of experiment. Mice were analyzed 5 weeks after AAV injection. c Representative micrographs of Arg1 overexpression characteristically in hippocampal microglia. d Total distance of the adult offspring in open field test. n = 10 per group; F 3, 36 = 5.471, P < 0.05, one-way ANOVA. e Similar response to 70 dB background noise in the three group. f PPI was impaired in Poly offspring compared with Ctrl offspring and ameliorated in Poly+AAV-DIO-Arg1-GFP offspring. n = 10 mice per group. Group: F 3, 36 = 8.963, P < 0.05; Pepulse intensity: F 2, 72 = 18.61, P < 0.001; Group × Prepulse intensity: F 6, 72 = 0.554, P > 0.05, two-way ANOVA with repeated measures. g Increased latency for Poly offspring to locate the hidden platform, compared to Ctrl offspring, and decreased in Poly+AAV-DIO-Arg1-GFP offspring. n = 10 mice per group. Group: F 3, 36 = 4.873, p < 0.05; Day: F 3, 108 = 13.719, p < 0.01; Group × day: F 9, 108 = 2.824, p > 0.05, two-way ANOVA with repeated measures. h In the probe trial, data are presented as percent time and percent distance in the target quadrant. n = 10 mice per group, F 3, 36 = 3.568, P < 0.05, one-way ANOVA. For Fig. g * p < 0.05, ** p < 0.01 for Poly offspring vs. Ctrl offspring; # p < 0.05 for Poly+AAV-DIO-Arg1-GFP offspring vs. Poly offspring. Values are the mean ± SEM. * p < 0.05, ** p < 0.01, n.s., not significant.

Journal: Neuropsychopharmacology

Article Title: Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus

doi: 10.1038/s41386-020-0743-7

Figure Lengend Snippet: a Schematic diagram showing the experimental strategy for Arg1 overexpression. AAV-DIO-Arg1-GFP was stereotactic injected into hippocampus DG of CX3CR1-creER mice. b Timeline of experiment. Mice were analyzed 5 weeks after AAV injection. c Representative micrographs of Arg1 overexpression characteristically in hippocampal microglia. d Total distance of the adult offspring in open field test. n = 10 per group; F 3, 36 = 5.471, P < 0.05, one-way ANOVA. e Similar response to 70 dB background noise in the three group. f PPI was impaired in Poly offspring compared with Ctrl offspring and ameliorated in Poly+AAV-DIO-Arg1-GFP offspring. n = 10 mice per group. Group: F 3, 36 = 8.963, P < 0.05; Pepulse intensity: F 2, 72 = 18.61, P < 0.001; Group × Prepulse intensity: F 6, 72 = 0.554, P > 0.05, two-way ANOVA with repeated measures. g Increased latency for Poly offspring to locate the hidden platform, compared to Ctrl offspring, and decreased in Poly+AAV-DIO-Arg1-GFP offspring. n = 10 mice per group. Group: F 3, 36 = 4.873, p < 0.05; Day: F 3, 108 = 13.719, p < 0.01; Group × day: F 9, 108 = 2.824, p > 0.05, two-way ANOVA with repeated measures. h In the probe trial, data are presented as percent time and percent distance in the target quadrant. n = 10 mice per group, F 3, 36 = 3.568, P < 0.05, one-way ANOVA. For Fig. g * p < 0.05, ** p < 0.01 for Poly offspring vs. Ctrl offspring; # p < 0.05 for Poly+AAV-DIO-Arg1-GFP offspring vs. Poly offspring. Values are the mean ± SEM. * p < 0.05, ** p < 0.01, n.s., not significant.

Article Snippet: The Arg1 overexpression AAV (pAAV-CMV-DIO-Arg1-eGFP-2A, 9.38 × 10 12 VG/ml), and control AAV for Arg1 overexpression AAV (2.31 × 10 12 VG/ml), with a serotype of AAV9, were purchased from Sunbio Medical Biotechnology (Shanghai, China).

Techniques: Over Expression, Injection